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The Big Pharma said it was ending ARMO BioSciences is a late-stage immuno-oncology company that is developing a pipeline of novel cytokine-based therapeutics that activate the immune system of cancer patients to recognize and eradicate tumors. INDIANAPOLIS, June 22, 2018 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY) today announced the successful completion of its acquisition of ARMO BioSciences, Inc. (NASDAQ: ARMO). Lilly's tender offer for all outstanding shares of common stock of ARMO, at a price of $50.00 per share in cash, expired as scheduled on Thursday, June 21, 2018. ARMO BioSciences, Inc.(ARMO)产品线（产品百科）： AM0010（pegilodecakin）——公司首要候选产品，是一种长效的重组人白细胞介素10（IL-10）。IL-10是人体中天然存在的免疫生长因子，其可刺激（激活）免疫系统中特定类型的白细胞（CD8+ T cells）的存活、扩增和杀伤潜力。 2018-05-10 · ARMO Biosciences has a simple yet promising approach to immunotherapy. The lead drug candidate, AM0010, comprises a recombinant human growth factor called interleukin-10 (IL-10) attached to 2018-05-18 · Eli Lilly announced that it is acquiring ARMO BioSciences and its lead candidate pegilodecakin (AM0010), an investigational immunotherpay that has shown clinical benefit in multiple types of cancer and is now in a pivotal study in pancreatic cancer patients.

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4 ARMO BioSciences, Eli Lilly and Company, Redwood City, CA, USA. 5 Memorial Sloan Kettering Cancer Center, New York, NY, USA. 6 University of California Los Angeles (UCLA), Los Angeles, CA, USA. to acquire Armo BioSciences Inc. last year, giving Lilly a long-acting pegylated form of recombinant IL-10Sanofi expects to complete the deal next quarter. Targets: IL-2 - Interleukin-2; IL-10 - Interleukin-10 Background: IL-10 induces activation of STAT3 in CD8 T cells leads to increased survival, proliferation and cytotoxicity of CD8 T cells. In preclinical studies, PEG-IL-10 induces CD8 mediated tumor rejection and synergizes with cytotoxic chemotherapies. Anti-tumor activity of AM0010 alone was established in the ongoing phase 1 basket trial. The IL-10 project pegilodecakin at least failed fairly fast for Lilly, though this is where the positives end. Lilly’s $1.6bn acquisition of Armo Biosciences in May 2018, when cytokines were being described as the next big thing, now looks rash, and hopes for this approach to treating cancer have dimmed substantially since then.

High concentrations of IL-10 activate an immune response against cancer cells. Armo is developing IL-10 drugs for potential combination with established immunotherapies Eli Lilly is looking to keep pace with the leaders in immuno-oncology sector, and has just agreed a $1.6bn acquisition of Armo BioSciences to help close the gap. 4 ARMO BioSciences, Eli Lilly and Company, Redwood City, CA, USA. 5 Memorial Sloan Kettering Cancer Center, New York, NY, USA. 6 University of California Los Angeles (UCLA), Los Angeles, CA, USA. Patients receiving the long-acting pegylated form of recombinant IL-10..a mAb against checkpoint protein TIM3.

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The company was founded in 1876 by, and named after, Col. Eli Lilly, a pharmaceutical chemist and veteran of the American Civil War. Lilly's notable achievements include being the first company to mass-produce the ARMO BIOSCIENCES, INC. (Exact name of Registrant as specified in its charter) Our lead product candidate, AM0010, is a long acting form of IL-10 that we have developed. Eli Lilly and Company (NYSE: LLY) and ARMO BioSciences, Inc. (NASDAQ: ARMO) today announced a definitive agreement for Lilly to acquire ARMO for $50 per share, or approximately $1.6 billion, in an all-cash transaction. ARMO BioSciences is a late-stage immuno-oncology company that is developing a pipeline of novel, p 2018-05-11 REDWOOD CITY, Calif., Aug. 29, 2017 /PRNewswire/ -- ARMO BioSciences, Inc., a late-stage immuno-oncology company, today announced the successful completion of a $67 million Series C-1 private Shares of ARMO BioSciences have soared more than 67 percent in premarket trading after Eli Lilly announced it had struck a deal to acquire the Redwood City, Calif,-based company for $1.6 billion in an all cash deal.. This morning Lilly said the acquisition of Armo and its lead product candidate pegilodecakin will bolster the company’s immuno-oncology programs.

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2019-10-16 Armo BioSciences is a Silicon Valley-based immune-oncology company that recently launched its $128M IPO on Nasdaq. The key molecule, AM0010 (pegilodecakin), is a long-acting form of human IL-10. PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8 + T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients 4 ARMO BioSciences, Eli Lilly and Company, Redwood City, CA, USA. 5 Memorial Sloan Kettering Cancer Center, New York, NY, USA. Well along in the clinic with a mix of second-wave immuno-oncology programs in early-stage studies, Armo BioSciences has lined up $50 million in funding to pay for pivotal stage development.

IL-10 is a reported alias name for the human gene IL10, or 'interleukin 10'. The 178-amino acid protein is a member of the IL-10 family. The cellular localization is predicted to be secreted.
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9, 2017 /PRNewswire/ -- ARMO BioSciences, Inc., a late-stage immuno-oncology company, today announced that clinical trial results on its lead investigational immuno-oncology drug AM0010 (pegilodecakin, PEGylated Interleukin-10) are being reported at the European Society of Medical Oncology (ESMO) 2017 Congress being held in Madrid, Spain, September 8-12, 2017.   ARMO Biosciences has a simple yet promising approach to immunotherapy.

Armo is repurposing the program for cancer based on new evidence that it can stimulate a T cell response against tumor cells. ARMO BioSciences, Inc.(ARMO)产品线（产品百科）： AM0010（pegilodecakin）——公司首要候选产品，是一种长效的重组人白细胞介素10（IL-10）。IL-10是人体中天然存在的免疫生长因子，其可刺激（激活）免疫系统中特定类型的白细胞（CD8+ T cells）的存活、扩增和杀伤潜力。 Armo BioSciences is a Silicon Valley-based immune-oncology company that recently launched its $128M IPO on Nasdaq. The key molecule, AM0010 (pegilodecakin), is a long-acting form of human IL-10. 2018-05-18 · Eli Lilly announced that it is acquiring ARMO BioSciences and its lead candidate pegilodecakin (AM0010), an investigational immunotherpay that has shown clinical benefit in multiple types of cancer and is now in a pivotal study in pancreatic cancer patients.
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Commissioned Research: Cantargia Nordea Markets

PEGylated IL-10 (pegilodecakin or AM0010 Armo’s scientists increased the size of IL-10 by linking it to polyethylene glycol to prolong its circulation time in the body to maximize its activation of antitumor CD8+ T cells. So far, it has been studied in more than 350 people with cancer across more that 14 tumor types. Ilodecakin - ARMO Biosciences/Merck & Co Alternative Names: AM 0010; LY-3500518; PEG-ilodecakin; PEG-rHuIL-10; Pegilodecakin - ARMO Biosciences/Merck & Co; PEGylated Human IL-10; PEGylated Interleukin-10; PEGylated recombinant human Interleukin-10 Latest Information Update: 28 Dec 2020 Eli Lilly and Co said on Thursday it would buy Armo BioSciences Inc for about $1.6 billion to expand its portfolio of drugs that helps body's immune system fight cancer as the U.S. drugmaker Prior to ARMO, he held R&D positions with increasing levels of responsibility at Anergen, Introgen Therapeutics, Bacterial Barcodes and Momentum BioVentures.